Wanda Thompson was born in a small rural town in Florida. Her father served in the military and her mother was a teacher. Early in her life Thompson moved around due to her father’s job, and has lived in places like Germany, France, California, and Georgia, before moving to the Hilltop area of Tacoma. She attended the all-girls Catholic academy, Aquinas Academy, which in 1974 combined with an all-boys Catholic academy to form Bellarmine Preparatory School. She won Ms. Hilltop in 1969 and ran for Ms. Downtown Tacoma in 1980.

After high school Thompson attended Evergreen State College and studied cultural anthropology and journalism. While at Evergreen she also studied abroad in France. Out of college her first job was at the Tacoma Public Library in the genealogy department. From there she went on to work at the Puget Sound National Bank, Civic Arts Commission, Fashion Fair Cosmetics, the Washington State Department of Corrections, and the Rehabilitation Council of Washington to name a few. Thompson has been involved in the Tacoma community through her involvement with organizations like the Tacoma Urban League, the Tacoma Downtown Association, and the Afro-Pageant and Show. She is also a published author.